The Center for Health Economics of Treatment Interventions for Substance Use Disorders, HCV, and HIV (CHERISH) is a multi-institutional Center of Excellence, funded by the National Institute on Drug Abuse. The Center’s mission is to develop and disseminate health economic research on healthcare utilization, health outcomes, and health-related behaviors that informs substance use disorder treatment policy and HCV and HIV care of substance users. To increase the impact of this research, we support researchers in addressing the needs of integrated healthcare system providers and payers. CHERISH is funded by NIDA (P30DA040500) as a collaboration among Weill Cornell Medicine, Boston Medical Center, Boston University School of Public Health, University of Pennsylvania, and University of Miami Miller School of Medicine.