The Chordata protein annotation project focuses on the manual annotation of chordata-specific proteins as well as those that are widely conserved. The aim of this project is twofold: 1. to keep the existing human entries up-to-date and 2. to broaden the manual annotation to other vertebrate species, especially model organisms, including great apes, cow, mouse, rat, chicken, zebrafish, as well as Xenopus laevis and Xenopus tropicalis.
A draft of the complete human proteome has been available in UniProtKB/Swiss-Prot since 2008 and one of the current priorities of the Chordata protein annotation project is to improve the quality of human sequences provided.