The Science of Behavior Change (SOBC) seeks to improve the understanding of underlying mechanisms of human behavior change by promoting research on the initiation, personalization, and maintenance of behavior change. SOBC aims to bring together basic and applied scientists across health-related behaviors, such as diet, exercise, and medication adherence, in order to develop more effective behavioral interventions. SOBC research is funded by the SOBC Common Fund Program in the Office of Strategic Coordination, Office of the Director of the National Institutes of Health (NIH). Common Fund programs resonate with the missions of multiple Institutes, Centers, and Offices at the NIH. Its programs are intended to be transformative, cross-cutting, and unique. NIH staff from more than 15 Institutes, Centers, and Offices are involved in SOBC research and several of them are active members of the SOBC Research Network as Program Officials and Project Scientists associated with Network projects.