20:59

1 BILLION ENEMIES vs .. isaac

13:05

First Ever ISAAC HUNGER GAMES

22:46

I Was Challenged to an Isaac Race.. but in Cars

26:22

Isaac Speedruns are INSANE

31:16

Isaac, but Every 5 Minutes You Make it WEIRD

13:23

Can Twitch Chat beat ONE FLOOR in Isaac?

18:53

How to Break Greedier with ONLY 8 Items

29:12

The ULTIMATE Isaac Race: The Wiz vs 20/20

25:29

Isaac Lockout Bingo is Surprisingly Difficult..

34:14

I was Invited to an Isaac Gameshow..

36:47

Beating Isaac the Way Edmund Intended

22:02

This Isaac Pro Challenged Me to One FINAL Bingo Match

47:20

An Authentic Isaac Video Where I Talk Over Gameplay

38:58

If Chat Makes Me Laugh I Reset the Run

28:07

I Challenged This Isaac Pro to ANOTHER Test of Skill

05:10:21

Ranking Isaac ACTIVE ITEMS by Their USEFULNESS

34:29

The Most Unconventional "Break"

34:19

Isaac Bingo but there are 3 Boards.. it's INTENSE

34:36

4 Isaac Pros vs Tainted Lost ft. @Hutts @SlayXc2 @vicfis_

29:06

Isaac's First NEGATIVE Quality Item

36:28

Proof that Youtuber Luck is REAL

28:44

Multiplayer Ultra Hard is even WORSE than you think

20:08

I Challenged an Isaac Pro to a 1v1

46:25

The Isaac Online Experience ft. @Lonslo & @noromeLIVE

24:41

31 NEW CHANGES in Repentance+

59:35

I Made a BIG Mistake .. ft @Ujary

46:32

Chaos Deniers are WRONG. Here's the proof.

08:27:17

I Hosted Isaac's LARGEST Influencer Tournament [FULLY EDITED]

22:13

Isaac's SPOOKIEST Run

01:21:26

Isaac's HARDEST Quiz ft Vicfis

44:18

Why Tainted Cain is S+ TIER

28:30

Beating Isaac's Unreleased Content

29:26

The Isaac Race where I Gamble it ALL

22:00

Name this Isaac THING. I know you can't.

30:56

Ranking Isaac CURSES by How Bad They Need an Update

39:55

Rock Bottom is TERRIBLE. Here's the proof.

33:11

Name these 10 Isaac THINGS. I bet you can't.

33:08

This is NOT Isaac Jeopardy

58:26

Ranking Isaac BIRTHRIGHTS By Their USEFULNESS

53:29

Beating Isaac using ONLY Breath of Life.. as Tainted Lost... Blindfolded

42:44

This Isaac Pro Thought They Could Beat Me.. Again

55:14

The SCUFFED Isaac Quiz Ft... Twitch Chat?!?

28:57

Isaac TRANSFORMATIONS Ranked By Their IMPACT

01:07:05

I Challenged an Isaac Pro to a True Test of Skill

56:36

Your Isaac Challenge Ideas Are Terrible

10:08

I Paid Fiverr Editors to Make HYPE Binding of Isaac Edits

40:32

Isaac PILLS Ranked by USEFULNESS

25:17

Isaac's "HARDEST" Challenge

24:27

The Future of Isaac Sequels

34:09

First Ever Isaac Co-Op BINGO

32:38

Beating an IMPOSSIBLE Run.. It was a mistake

01:06:48

Isaac CHARACTERS Tips & Tricks

25:01

If Isaac Gets Hit .. the Video Ends?

26:44

I Made Isaac Into a RAGE GAME

28:49

Isaac Jeopardy but No One Is Allowed to Win

24:04

Beating Isaac's HARDEST Seed .. I Regret it

29:05

Isaac Youtuber Tier List.. Please don't cancel me

40:31

I Beat the HARDEST Isaac Run. It was a mistake.

46:37

The Least Rigged Isaac Quiz Ft. Albino

39:25

Isaac 2v2 LOCKOUT ft. @Hutts @noromeLIVE & Kemz!!!!